Efficacy of CTZ antibiotic paste in non-instrumented endodontic treatments in necrotic primary teeth.

Abstract

Introduction: Pulpal treatments in primary teeth have increasingly become a challenge for pediatric dentists, to be able to perform them successfully due to issues of effectiveness in terms of antimicrobial activity and biocompatibility. Instrumented pulpectomy is the ideal treatment but it is a long and complicated procedure, which is why non-instrumented endodontic techniques have been proposed with antibiotic pastes such as CTZ, which contains two antibiotics (chloramphenicol and tetracycline) and zinc oxide and eugenol. Objective: The objective of this study is to carry out a bibliographic review of the CTZ antibiotic paste, its antimicrobial capacity, biocompatibility and its clinical aspects. Materials and methods: The search was carried out in the Google Scholar, Scielo and PubMed databases in the years from 2018 to 2022 in English and Spanish, replicated articles were eliminated, leaving 13 articles. Results: The studies showed that CTZ antibiotic paste has good antimicrobial activity against Enterococcus faecalis, Streptococcus aureus and Candida albicans. In Vitro studies showed that the paste has low cytotoxicity at 1:1 and 1:2 concentrations, it seems to decrease with exposure time and it has good biocompatibility . Conclusions: Although the information presented is scarce, it can be affirmed that the CTZ antibiotic paste is an adequate option for the treatment of pulpal necrosis in primary teeth, due to its antimicrobial effectiveness, biocompatibility and feasibility of handling, since it reduces the time of worked.